Solution Found!
Solution: Propose an efficient synthesis for the following
Chapter 22, Problem 22.99(choose chapter or problem)
Propose an efficient synthesis for the following transformation: O
Questions & Answers
QUESTION:
Propose an efficient synthesis for the following transformation: O
ANSWER:Step 1 of 4
Propose an efficient synthesis for the following transformation.
Our first goal needs to be breaking open the cyclopentene ring. We can always close up a six-membered ring later on, but having five carbons locked into a ring limits our synthetic flexibility. Thankfully, we know of a reaction which “scissors” alkenes horizontally, capping each carbon fragment with a carbonyl group; applied here, the ring would open up into a straight-chain compound. From here, we could use an aldol reaction to form the general shape of the desired cyclohexanone product. Applying some finishing touches would then lead to the needed material.