Nicotine is well known for its addictive characteristic in

Chapter 23, Problem 23.9

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Nicotine is well known for its addictive characteristic in cigarettes. Interestingly, it has also been suggested to have potential therapeutic potential in central nervous system disorders such as Alzheimers disease, Parkinsons disease, and depression. However, due to the toxic side effects of nicotine, derivatives are being developed, such as compound 2, which shows much lower toxicity and exhibits analgesic (pain-inhibiting) properties (Bioorg. Med. Chem. Lett. 2006, 16, 20132016). Suggest an efficient synthesis of compound 2 from compound 1. N Cl HO2C N Cl N H 1 2

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