A pharmaceutical product is designed to be absorbed inthe
Chapter 14, Problem 14.45(choose chapter or problem)
A pharmaceutical product is designed to be absorbed inthe gastrointestinal tract. The active ingredient is pressedinto a tablet with a density of ?A?15 kg/m3while theremainder of the tablet is composed of inactive ingredi-ents. The partition coefficient is K?3?10?2, and thediffusion coefficient of the active ingredient in the gas-trointestinal fluid is DAB?0.4?1010m2/s.(a) Estimate the dosage delivered over a time periodof 5 h for a spherical tablet of diameter D?6 mm. Hint: Assume the change in the tabletradius over the dosage period is small.(b) Estimate the dosage delivered over 5 h forN?200 small, spherical tablets contained in agelatin capsule that quickly dissolves after inges-tion, releasing the medication. The initial mass ofthe medication is the same as in part (a).
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