The enzyme carbonic anhydrase catalyzes the reaction

Chapter , Problem 14.85

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The enzyme carbonic anhydrase catalyzes the reaction CO21g2 + H2O1l2 HCO3 - 1aq2 + H+1aq2. In water, without the enzyme, the reaction proceeds with a rate constant of 0.039 s -1 at 25 C. In the presence of the enzyme in water, the reaction proceeds with a rate constant of 1.0 * 106 s -1 at 25 C. Assuming the collision factor is the same for both situations, calculate the difference in activation energies for the uncatalyzed versus enzyme-catalyzed reaction.

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