Which of the following compounds can be resolved into enantiomers at room temperature? Explain. (a) (b) (c) N N CH3 CH3 CH3 H3C .. .. (d)
Chapter 19 Comparing acidities of compounds ● Pka o high pka is a weak acid o low pka is a strong acid o HI pka ~ -10 o CH4 pka ~ 50 o Evans pka = website good for finding pka values of various acids All mean the same thing ● Reactive ● Strong ● Unstable All mean the same thing ● Unreactive ● Weak ● Stable An acid’s strength is predicted by the stability of its conjugate base ● exothermic equilibrium constant > 1 ● Endothermic equilibrium constant < 1 ● The stability of ions is highly variable ● Stability of neutral compounds is less variable Inductive effects = electron withdrawing or donating through O bond framework ● EWG(electron withdrawing group) = induces a partial +, increase