Enediynes are natural products with potent antitumor properties because they are able to
Chapter 13, Problem 48(choose chapter or problem)
Enediynes are natural products with potent antitumor properties because they are able to cleave DNA (page 299 ). Their cytotoxic properties are due to the enediyne undergoing a cyclization to form a highly reactive diradical intermediate. The intermediate abstracts hydrogen atoms from the backbone of DNA, which triggers its damage. Draw the structure of the diradical intermediate.
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