Cocaine has been prepared by a sequence beginning with a Mannich reaction ( 23.64)
Chapter 23, Problem 23.65(choose chapter or problem)
Cocaine has been prepared by a sequence beginning with a Mannich reaction ( 23.64) between dimethyl acetonedicarboxylate, an amine, and a dialdehyde. Show the structures of the amine and dialdehyde. CH3O2C O N Cocaine + + Amine Dialdehyde CH3O2C CO2CH3 CO2CH3 CO2CH3 OCOPh O CH3 N CH3
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