Solved: In glycerol metabolism, the oxidation of sn-glycerol 3-phosphate to give

Chapter 29, Problem 29.42

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In glycerol metabolism, the oxidation of sn-glycerol 3-phosphate to give dihydroxyacetone phosphate is catalyzed by sn-glycerol-3-phosphate dehydrogenase, with NAD1 as cofactor. The reaction is stereospecific, occurring exclusively on the Re face of the nicotinamide ring. CONH2 H NAD+ N+ CONH2 H NADH H N Dihydroxyacetone Which hydrogen in the NADH product comes from sn-glycerol 3-phosphate?Does it have pro-R or pro-S stereochemistry?

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