Solved: The amino acid tyrosine is biologically degraded by a series of steps that

Chapter 29, Problem 29.50

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The amino acid tyrosine is biologically degraded by a series of steps that include the following transformations: Maleoylacetoacetate Fumaroylacetoacetate Tyrosine CO2 CO2 O O CO2 O2C O O Acetoacetate Fumarate CO2 + O O2C CO2 CH3CSCoA O The double-bond isomerization of maleoylacetoacetate to fumaroylacetoacetate is catalyzed by practically any nucleophile, :Nu2. Propose a mechanism.

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