Chromatographymass spectrometry. HPLC separation of enantiomers of the drug Ritalin on a
Chapter 24, Problem 24-23(choose chapter or problem)
Chromatography-mass spectrometry. HPLC separation of enantiomers of the drug Ritalin on a chiral stationary phase was shown in 24-11.
(a) Detection is by atmospheric pressure chemical ionization with selected reaction monitoring of the \(m / z \quad 234 \rightarrow 84\) transition. Explain how this detection works and propose structures for \(\mathrm{m}/\mathrm{z}\ 234\) and \(\mathrm{m}/\mathrm{z}\ 84\).
(b) For quantitative analysis, the internal standard 2 H3-Ritalin with a deuterated methyl group was added. Deuterated enantiomers have the same retention times as unlabeled enantiomers. Which selected reaction monitoring transition should be monitored to produce a chromatogram of the internal standard in which unlabeled Ritalin will be invisible?
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