The article Improved Bioequivalence Assessment of Topical Dermatological Drug Products

Chapter 2, Problem 3

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The article “Improved Bioequivalence Assessment of Topical Dermatological Drug Products Using Dermatopharmacokinetics” (B. N’Dri-Stempfer, W. Navidi, et al., Pharmaceutical Research, 2009:316–328) describes a study in which a new type of ointment was applied to forearms of volunteers to study the rates of absorption into the skin. Eight locations on the forearm were designated for ointment application. The new ointment was applied to four locations, and a control was applied to the other four. How many different choices were there for the four locations to apply the new ointment?

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