Let A and B represent two variants (alleles) of the DNA at a certain locus on the

Chapter 3, Problem 6

(choose chapter or problem)

Let \(A \text { and } B\) represent two variants (alleles) of the DNA at a certain locus on the genome. Let  represent the proportion of alleles in a population that are of type , and let  represent the proportion of alleles that are of type . The Hardy-Weinberg equilibrium principle states that the proportion \(P_{A B}\) of organisms that are of type \(A B\) is equal to \(p q\). In a population survey of a particular species, the proportion of alleles of type  is estimated to be \(0.360 \pm 0.048\) and the proportion of alleles of type  is independently estirnaled to be \(0.250=0.043\)

a. Estimate the proportion of organisms that are of type \(A B\), and find the uncertainty in the estimate.

b. Find the relative uncertainty in the estimated proportion.

c. Which would provide a greater reduction in the uncertainty in the proportion: reducing the uncertainty in the type  proportion to  or reducing the uncertainty in the type  proportion to

Equation Transcription:

   

     

   

   

 

Text Transcription:

A and B  

P_AB    

AB  

pq    

0.360 \pm 0.048  

0.250=0.043

AB