In experiments to determine the effectiveness of drugs such as anti-fungal ointments
Chapter 5, Problem 7(choose chapter or problem)
In experiments to determine the effectiveness of drugs such as antifungal ointments that are applied to the skin, the concentration of the drug in a patient’s skin must be measured. The article “Determining Bioequivalence of Topical Dermatological Drug Products by Tape-Stripping” (W. Navidi, A. Hutchinson, et al., Journal of Pharmacokinetics and Pharmacodynam- ics, 2008:213–220) describes an improved method of measuring that is designed to ensure that all the drug in the skin is recovered. Assume that in an experi- ment using the old method, the mean amount of drug recovered from a sample of 49 patients was \(105 \mathrm{ng}\) with a standard deviation of \(20 \mathrm{ng}\), and that in an experiment using the new method the mean amount of drug recovered in a sample of 35 patients was \(117 \mathrm{ng}\) with a standard deviation of \(15 \mathrm{ng}\). Find a 98% confidence interval for the difference in the mean amounts recovered between the two methods.
Equation Transcription:
Text Transcription:
105 ng
20 ng
117 ng
15 ng
98%
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