Solution Found!
Analyzing Journal Article Results Researchers (Brian G.
Chapter 1, Problem 26AYU(choose chapter or problem)
Analyzing Journal Article Results Researchers (Brian G. Feagan et al., “Erythropoietin with Iron Supplementation to Prevent Allogeneic Blood Transfusion in Total Hip Joint Arthroplasty,” Annals of Internal Medicine, Vol. 133, No. 11) wanted to determine whether epoetin alfa was effective in increasing the hemoglobin concentration in patients undergoing hip arthroplasty. The researchers screened patients for eligibility by performing a complete medical history and physical of the patients. Once eligible patients were identified, the researchers used a computer-generated schedule to assign the patients to the high-dose epoetin group, low-dose epoetin group, or placebo group. The study was double-blind. Based on an analysis of variance, it was determined that there were significant differences in the increase in hemoglobin concentration in the three groups with a P-value less than 0.001. The mean increase in hemoglobin in the high-dose epoetin group was 19.5 grams per liter (g/L), the mean increase in hemoglobin in the low-dose epoetin group was 17.2 g/L, and mean increase in hemoglobin in the placebo group was 1.2 g/L.
(a) Why do you think it was necessary to screen patients for eligibility?
(b) Why was a computer-generated schedule used to assign patients to the various treatment groups?
(c) What does it mean for a study to be double-blind? Why do you think the researchers desired a double-blind study?
(d) Interpret the reported P-value.
Questions & Answers
QUESTION:
Analyzing Journal Article Results Researchers (Brian G. Feagan et al., “Erythropoietin with Iron Supplementation to Prevent Allogeneic Blood Transfusion in Total Hip Joint Arthroplasty,” Annals of Internal Medicine, Vol. 133, No. 11) wanted to determine whether epoetin alfa was effective in increasing the hemoglobin concentration in patients undergoing hip arthroplasty. The researchers screened patients for eligibility by performing a complete medical history and physical of the patients. Once eligible patients were identified, the researchers used a computer-generated schedule to assign the patients to the high-dose epoetin group, low-dose epoetin group, or placebo group. The study was double-blind. Based on an analysis of variance, it was determined that there were significant differences in the increase in hemoglobin concentration in the three groups with a P-value less than 0.001. The mean increase in hemoglobin in the high-dose epoetin group was 19.5 grams per liter (g/L), the mean increase in hemoglobin in the low-dose epoetin group was 17.2 g/L, and mean increase in hemoglobin in the placebo group was 1.2 g/L.
(a) Why do you think it was necessary to screen patients for eligibility?
(b) Why was a computer-generated schedule used to assign patients to the various treatment groups?
(c) What does it mean for a study to be double-blind? Why do you think the researchers desired a double-blind study?
(d) Interpret the reported P-value.
ANSWER:Step 1 of 5
From the research we can see that the epoetin alfa is effective in increasing the hemoglobin concentration in patients undergoing hip arthroplasty