Represent the electrical network shown in Figure P3.1 in state space, where \(v_o(t)\) is the output. [Section: 3.4]
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Textbook Solutions for Control Systems Engineering
Question
In the past, Type-1 diabetes patients had to inject themselves with insulin three to four times a day. New delayed-action insulin analogues such as insulin Glargine require a single daily dose. A similar procedure to the one described in the Pharmaceutical Drug Absorption case study of this chapter is used to find a model for the concentration-time evolution of plasma for insulin Glargine. For a specific patient, state-space model matrices are given by (Tarín, 2007)
\(\begin{aligned} & \mathbf{A}=\left[\begin{array}{ccc} -0.435 & 0.209 & 0.02 \\ 0.268 & -0.394 & 0 \\ 0.227 & 0 & -0.02 \end{array}\right] ; \quad \mathbf{B}=\left[\begin{array}{l} 1 \\ 0 \\ 0 \end{array}\right] ; \\ & \mathbf{C}=\left[\begin{array}{lll} 0.0003 & 0 & 0 \end{array}\right] ; \quad \mathbf{D}=0 \end{aligned}\)
where the state vector is given by
\(\mathbf{x}=\left[\begin{array}{l} x_1 \\ x_2 \\ x_3 \end{array}\right]\) .
The state variables are
\(x_1=\) insulin amount in plasma compartment
\(x_2=\) insulin amount in liver compartment
\(x_3=\) insulin amount in interstitial (in body tissue) compartment
The system’s input is u= external insulin flow.
The system’s output is y= plasma insulin concentration.
(a) Find the system’s transfer function.
(b) Verify your result using MATLAB.
Solution
The first step in solving 3 problem number 22 trying to solve the problem we have to refer to the textbook question: In the past, Type-1 diabetes patients had to inject themselves with insulin three to four times a day. New delayed-action insulin analogues such as insulin Glargine require a single daily dose. A similar procedure to the one described in the Pharmaceutical Drug Absorption case study of this chapter is used to find a model for the concentration-time evolution of plasma for insulin Glargine. For a specific patient, state-space model matrices are given by (Tarín, 2007)\(\begin{aligned} & \mathbf{A}=\left[\begin{array}{ccc} -0.435 & 0.209 & 0.02 \\ 0.268 & -0.394 & 0 \\ 0.227 & 0 & -0.02 \end{array}\right] ; \quad \mathbf{B}=\left[\begin{array}{l} 1 \\ 0 \\ 0 \end{array}\right] ; \\ & \mathbf{C}=\left[\begin{array}{lll} 0.0003 & 0 & 0 \end{array}\right] ; \quad \mathbf{D}=0 \end{aligned}\)where the state vector is given by\(\mathbf{x}=\left[\begin{array}{l} x_1 \\ x_2 \\ x_3 \end{array}\right]\) .The state variables are\(x_1=\) insulin amount in plasma compartment\(x_2=\) insulin amount in liver compartment\(x_3=\) insulin amount in interstitial (in body tissue) compartmentThe system’s input is u= external insulin flow. The system’s output is y= plasma insulin concentration. (a) Find the system’s transfer function. (b) Verify your result using MATLAB.
From the textbook chapter MODELING IN THE TIME DOMAIN you will find a few key concepts needed to solve this.
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