Within a few weeks oftreatment with the drug 3TC, a

Chapter 0, Problem 4

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Within a few weeks oftreatment with the drug 3TC, a patient's HIV population consists entirely of3TC-resistant viruses. How can this result best he explained? a. HIV can change its surface proteins and resist vaccines. b. The patient must have become reinfected with 3TCresistant viruses. c. HIV began making drug-resistant versions of reverse transcriptase in response to the drug. d. A few drug-resistant viruses were present at the start of treatment, and natural selection increased their frequency. e. The drug caused the HIV RNA to change.

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