Figure 4.115 shows the concentration of bemetizide (a diuretic) in the blood after
Chapter 4, Problem 73(choose chapter or problem)
Figure 4.115 shows the concentration of bemetizide (a diuretic) in the blood after single oral doses of 25 mg alone, or 25 mg bemetizide and 50 mg triamterene in combination. 28 If the minimum effective concentration in a patient is 40 ng/ml, compare the effect of combining bemetizide with triamterene on peak concentration, time to reach peak concentration, time until onset of effectiveness, and duration of effectiveness. Under what circumstances might it be wise to use the triamterene with the bemetizide? 6 12 18 24 30 20 40 60 80 Bemetezide alone Bemetezide + triamterene t (hours) concentration of bemetizide (ng/ml) Figure 4.115
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