A reaction involved in the metabolism of sugars is the splitting of

Chapter 22, Problem 22-83

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A reaction involved in the metabolism of sugars is the splitting of fructose-1,6-diphosphate to give glyceraldehyde3-phosphate and dihydroxyacetone phosphate. In the living system, this retro-aldol is catalyzed by an enzyme called aldolase; however, it can also be catalyzed by a mild base. Propose a mechanism for the base-catalyzed reaction. C O CH2 CH2 CH2 CH2OH CH2 HO C H CH OH CH OH fructose-1,6-diphosphate C O P O O O O dihydroxyacetone phosphate C CH OH O H glyceraldehyde-3-phosphate P O O O O O O P O O P O O O O aldolase or OH

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