The article Increases in Steroid Binding Globulins Inducedby Tamoxifen in Patients with

Chapter 12, Problem 64

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The article Increases in Steroid Binding Globulins Inducedby Tamoxifen in Patients with Carcinoma of the Breast (J.of Endocrinology, 1978: 219226) reports data on theeffects of the drug tamoxifen on change in the level of cortisol-binding globulin (CBG) of patients during treatment.With and , summary values are n 26,, and .a. Compute a 90% CI for the true correlation coefficient r.b. Test versus at level .05.c. In a regression analysis of y on x, what proportion ofvariation in change of cortisol-binding globulin levelcould be explained by variation in patient age within thesample?d. If you decide to perform a regression analysis with ageas the dependent variable, what proportion of variation inage is explainable by variation in CBG?

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