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SCIENTIFIC INQUIRY Epinephrine initiates a signal transduction pathway that produces
Chapter 11, Problem 10(choose chapter or problem)
SCIENTIFIC INQUIRY Epinephrine initiates a signal transduction pathway that produces cyclic AMP (cAMP) and leads to the breakdown of glycogen to glucose, a major energy source for cells. But glycogen breakdown is only part of the fight-or-flight response that epinephrine brings about; the overall effect on the body includes an increase in heart rate and alertness, as well as a burst of energy. Given that caffeine blocks the activity of cAMP phosphodiesterase, propose a mechanism by which caffeine ingestion leads to heightened alertness and sleeplessness
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QUESTION:
SCIENTIFIC INQUIRY Epinephrine initiates a signal transduction pathway that produces cyclic AMP (cAMP) and leads to the breakdown of glycogen to glucose, a major energy source for cells. But glycogen breakdown is only part of the fight-or-flight response that epinephrine brings about; the overall effect on the body includes an increase in heart rate and alertness, as well as a burst of energy. Given that caffeine blocks the activity of cAMP phosphodiesterase, propose a mechanism by which caffeine ingestion leads to heightened alertness and sleeplessness
ANSWER:Caffeine blocks the activity of the enzyme cAMP phosphodiesterase, which breaks down cAMP. This in turn leads to an increase in cAMP. At the same time, cAMP stimulates the action o