If you compare the frequency of the sixteen possible dinucleotide sequences in the E
Chapter 0, Problem 5-12(choose chapter or problem)
If you compare the frequency of the sixteen possible dinucleotide sequences in the E. coli and human genomes, there are no striking differences except for one dinucleotide, 5-CG-3. The frequency of CG dinucleotides in the human genome is significantly lower than in E. coli and significantly lower than expected by chance. Why do you suppose that CG dinucleotides are underrepresented in the human genome?
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