The origin of new cells of the pancreasfrom stem cells or from preexisting cellswas not
Chapter 0, Problem 22-7(choose chapter or problem)
The origin of new cells of the pancreasfrom stem cells or from preexisting cellswas not resolved until a decade ago, when the technique of lineage tracing was used to decide the issue. Using transgenic mice that expressed a tamoxifen-activated form of Cre recombinase under the control of the insulin promoter, which is active only in cells, investigators could remove an inhibitory segment of DNA and thereby allow expression of human placental alkaline phosphatase (HPAP), which can be detected by histochemical staining. After a pulse of tamoxifen that converted about 30% of cells in young mice to
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