Generation of induced pluripotent stem (iPS) cells was first accomplished using
Chapter 0, Problem 22-10(choose chapter or problem)
Generation of induced pluripotent stem (iPS) cells was first accomplished using retroviral vectors to carry the OSKM (Oct4, Sox2, Klf4, and Myc) set of transcription regulators into cells. The efficiency of fibroblast reprogramming was typically low (0.01%), in part because large numbers of retroviruses must integrate to bring about reprogramming and each integration event carries with it the risk of inappropriately disrupting or activating a critical gene. In what other ways, or other forms, do you suppose you might deliver the OSKM transcription regulators so as to avoid these problems?
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