The intracellular bacterial pathogen Salmonella typhimurium, which causes
Chapter 0, Problem 23-10(choose chapter or problem)
The intracellular bacterial pathogen Salmonella typhimurium, which causes gastroenteritis, injects effector proteins to promote its invasion into nonphagocytic host cells by the trigger mechanism. S. typhimurium first stimulates membrane ruffling to promote invasion, and then suppresses membrane ruffling once invasion is complete. This behavior is mediated in part by injection of two effector proteins: SopE, which promotes membrane ruffling and invasion, and SptP, which blocks the effects of SopE. Both effector proteins target the monomeric GTPase, Rac, which in its active form promotes membrane ruffling. How do you suppose SopE and SptP affect Rac activity? How do you suppose the effects of SopE and SptP are staggered in time if they are injected simultaneously?
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