The conjugation of alcohols containing nonpolar groups (for example, phenol) to
Chapter 25, Problem 25.33(choose chapter or problem)
The conjugation of alcohols containing nonpolar groups (for example, phenol) to glucuronic acids is a key process by which these alcohols can be transformed into, and excreted as, water-soluble derivatives called glucuronides in phase II metabolism. (See Eq. 8.11, p. 358.) These conjugation reactions involve the reaction of UDP-glucuronic acid and the alcohol catalyzed by a family of enzymes called UDP-glucuronyl transferases. (See Fig. P25.33.) What would you expect to find as key catalytic features in the active sites of these enzymes?
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