Solved: Triosephosphate isomerase (TIM) catalyzes the conversion of dihydroxyacetone
Chapter 22, Problem 45(choose chapter or problem)
Triosephosphate isomerase (TIM) catalyzes the conversion of dihydroxyacetone phosphate to glyceraldehyde-3-phosphate. The enzymes catalyticgroups are Glu 165 and His 95. In the first step of the reaction, these catalytic groups function as a general-base and a general-acid catalyst, respectively.Propose a mechanism for the reaction.
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