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The Wobble Concept: Explaining Codon Variability in Amino Acid Encodin

Chapter 12, Problem 8

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QUESTION: It is possible for the codons for a single amino acid to have the first two bases in common and to differ in the third base. Why is this experimental observation consistent with the concept of wobble?

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QUESTION: It is possible for the codons for a single amino acid to have the first two bases in common and to differ in the third base. Why is this experimental observation consistent with the concept of wobble?

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The concept of wobble refers to the flexibility in base pairing rules between the codon on mRNA and the anticodon on tRNA during protein synthesis. It explains that a codon's first two nucleotide bases on mRNA often have strict base-pairing rules with the corresponding nucleotide bases of the anticodon on tRNA. However, the third base of the codon and the anticodon pair with more flexibility, allowing for variations and non-standard base pairing.

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The Wobble Concept: Explaining Codon Variability in Amino Acid Encodin
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Join us as we delve into the intriguing world of genetic coding and discover how the concept of wobble accounts for variations in codons encoding a single amino acid.


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