Rank the following compounds in decreasing order of their reactivity toward the SN2 reactionwith sodium ethoxide 
methyl chloride tert-butyl iodide neopentyl bromide
isopropyl bromide methyl iodide ethyl chloride
Solution 18P
Factors that affect the rate of 
1. Nature of leaving group
2. Nature of the substrate
Weak bases are good leaving groups. In halogens, the leaving group order is as follows:
The substrate with less steric hindrance has a high reactivity towards the 
The substrate reactivity order is as follows:
Methyl halides are most reactive towards the 
Methyl iodide is most reactive towards the 
