From a set of streptonignic dose-response data, an
Chapter 12, Problem 12.60(choose chapter or problem)
From a set of streptonignic dose-response data, an experimenter desires to develop a relationship between the proportion of lymphoblasts sampled that contain aberrations and the dosage of streptonignic. Five dosage levels were applied to the rabbits used for the experiment. The data are as follows (see Myers, 1990, in the Bibliography):Dose Number of Number with (mg/kg) Lymphoblasts Aberrations 0 600 15 30 500 96 60 600 187 75 300 100 90 300 145 (a) Fit a logistic regression to the data set and thus estimate 0 and 1 in the modelp =1 1+e(0+1x),where n is the number of lymphoblasts, x is the dose, and p is the probability of an aberration. (b) Show results of 2-tests revealing the signicance of the regression coecients 0 and 1. (c) Estimate ED50 and give an interpretation.
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