Positron emission tomography (PET) is a medical imaging tech nique that produces a

Chapter 1, Problem 1.72

(choose chapter or problem)

Positron emission tomography (PET) is a medical imaging tech nique that produces a threedimensional picture of functional processes in the body, such as the brain uptake of glucose. PET imaging requires the introduction of [18F]-fluorine (a radioactive isotope of fluorine) into molecules and can be achieved by several routes, such as the following (Tetrahedron Lett. 2003, 44, 91659167): + ! @ 18F 18F C C H H H H Br N C C H H H H O C C H H H H H H N C C H H H H O C C C H H C H H H H H H H H Br H H (a) Identify the hybridization for every heteroatom (atom other than C or H) in the three compounds. Note: Throughout this chapter, all lone pairs were drawn. We will soon see (Chapter 2) that lone pairs are often omitted from structural drawings, because they can be inferred by the presence or absence of formal charges. In this problem, none of the lone pairs have been drawn. (b) Predict the bond angle of each C!N!C bond in the product. (c) Identify the type of atomic orbital(s) that contain the lone pairs on the oxygen atom in the product.