The natural product ()-N-methylwelwitindolinone C isothiocyanate is isolated from a
Chapter 22, Problem 22.113(choose chapter or problem)
The natural product ()-N-methylwelwitindolinone C isothiocyanate is isolated from a blue-green algae and has been identified as a promising compound to treat drug-resistant tumors. Compound X (R = protecting group) was utilized as a key synthetic intermediate in the synthesis of the natural product (J. Am. Chem. Soc. 2011, 133, 1579715799). Compound X can be prepared in a ring-forming reaction from compound Y under strongly basic conditions (excess NaNH2). N O H SCN Cl N O H H RO N O OR Br X Y N-methylwelwitindolinone C isothiocyanate Several steps
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