ntisense oligonucleotides are a new class of synthetic drugs, one of which has been
Chapter 26, Problem 26.34(choose chapter or problem)
ntisense oligonucleotides are a new class of synthetic drugs, one of which has been approved for use, with numerous others being developed and tested. An antisense drug is designed to have a sequence that is complementary to a portion of a messenger RNA of an organism connected with a disease. The rationale is that the oligonucleotide will bind to the mRNA and interfere with the biosynthesis of a particular protein. An antisense oligonucleotide proposed for treatment of ulcerative colitis has the sequence 5-GCC CAA GCT GGC ATC GCT CA-3. In the solid-phase synthesis of this drug, what nucleoside is attached to the controlled-pore glass bead? A. A C. C B. T D. G
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