Consider a mechanism for the helixcoil transition in which nucleation occurs in the
Chapter 22, Problem 22.33(choose chapter or problem)
Consider a mechanism for the helixcoil transition in which nucleation occurs in the middle of the chain: hhhh . . . 5hchh . . . hchh . . . 5cccc . . . We saw in Impact I22.1 that this type of nucleation is relatively slow, so neither step may be rate-determining. (a) Set up the rate equations for this mechanism. (b) Apply the steady-state approximation and show that, under these circumstances, the mechanism is equivalent to hhhh . . . cccc . . . . (c) Use your knowledge of experimental techniques and your results from parts (a) and (b) to support or refute the following statement: It is very difficult to obtain experimental evidence for intermediates in protein folding by performing simple rate measurements and one must resort to special flow, relaxation, or trapping techniques to detect intermediates directly.
Unfortunately, we don't have that question answered yet. But you can get it answered in just 5 hours by Logging in or Becoming a subscriber.
Becoming a subscriber
Or look for another answer