Alkylating agents are compounds capable of transferring an
Chapter 23, Problem 23.94(choose chapter or problem)
Alkylating agents are compounds capable of transferring an alkyl group to a suitable nucleophile, and they represent an important class of anticancer agents. These agents can transfer an alkyl group to DNA (in a cancer cell), causing structural changes that ultimately lead to cell death. The product of the following transformation, which occurs via two successive substitution reactions, was designed to act as an anticancer alkylating agent (Tetrahedron Lett. 2004, 45, 58075810). Draw a structure for this product. N N N N NH2 O OSiEt Et3SiO 3 H2N EtO2C Br Br DBU C29H50N6O5Si2
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