Yeast alcohol dehydrogenase catalyzes the reduction of acetaldehyde by NADH to ethanol
Chapter 19, Problem 19.2(choose chapter or problem)
Yeast alcohol dehydrogenase catalyzes the reduction of acetaldehyde by NADH to ethanol in the last step of anaerobic fermentation (see sidebar, Sec. 10.8, p. 487). .. NH2 R H H N OH C H H H3C H3C C H C O O NH2 R H N C O + alcohol dehydrogenase (enzyme) NADH NAD+ acetaldehyde ethanol (a) The structure of this enzyme shows a Zn2+ ion (held in place by coordination with several amino acid side chains of the enzyme) that is required for catalysis near the carbonyl of acetaldehyde. Propose a role for this metal ion in catalysis. (Hint: See Eq. 19.28a.) (b) Using your answer to part (a), draw a curved-arrow mechanism for this reduction in which the role of the Zn2+ ion is explicitly shown.
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