In response to signals from the nervous system, the

Chapter 20, Problem 36CI

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In response to signals from the nervous system, the hypothalamus secretes a polypeptide hormone known as gonad-otropin-releasing factor (GnRF), which stimulates the pituitary gland to release other hormones into the bloodstream. Two of these hormones are luteinizing hormone (LH) and follicle-stimulating hormone (FSH).GnRF is a decapeptide with the following primary structure:Glu — His — Tyr— Ser — Tyr — Gly — Leu — Arg — Pro — Gly.(19.1, 19.2, 19.3, 19.4, 20.5)a. What is the N-terminal amino acid in GnRF?________________b. What is the C-terminal amino acid in GnRF?________________c. Which amino acids in GnRF are nonpolar or polar neutral?________________d. Draw the condensed structural formulas for the acidic or basic amino acids at physiological pH.________________e. Draw the primary structure for the first three amino acids of GnRF, starting from the N-terminal amino acid at physiological pH.________________f. When the level of LH or FSH is high in the bloodstream, the hypothalamus stops secreting GnRF. What type of regulation of proteins does this represent? The hypothalamus secretes GnRF.

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