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The amidomalonate synthesis can be used to prepare amino
Chapter 25, Problem 25.58(choose chapter or problem)
QUESTION:
The amidomalonate synthesis can be used to prepare amino acids from alkyl halides. When the amidomalonat
Questions & Answers
QUESTION:
The amidomalonate synthesis can be used to prepare amino acids from alkyl halides. When the amidomalonat
ANSWER:Step 1 of 2
The amidomalonate synthesis involves the deprotonation of diethyl acetamidomalonate with a strong base such as sodium ethoxide, followed by quenching of the resulting anion with an alkyl halide. Upon aqueous hydrolysis combined with heat, this alkyl group becomes the R group in a racemic mixture of a generic -amino acid.