Genes participating in informational processes such as replication, transcription, and

Each member of the human hemoglobin gene family, which consists of seven genes arranged in two clusters on different chromosomes, is an ortholog to all of the other members.

Horizontal gene transfer is more prevalent in single-celled organisms than in multicellular organisms.

Most of the DNA sequences in a bacterial genome code for proteins, whereas most of the DNA sequences in the human genome do not.

Since it was deciphered four decades ago, some have claimed that the genetic code must be a frozen accident, while others have argued that it was shaped by natural selection. A striking feature of the genetic code is its inherent resistance to the effects of mutation. For example, a change in the third position of a codon often specifies the same amino acid or one with similar chemical properties. The natural code resists mutation more effectively (is less susceptible to error) than most other possible versions, as illustrated in Figure Q11. Only one in a million computer-generated random codes is more error-resistant than the natural genetic code. Does the extraordinary mutation resistance of the genetic code argue in favor of its origin as a frozen accident or as a result of natural selection? Explain your reasoning.

You have begun to characterize a sample obtained from the depths of the oceans on Europa, one of Jupiters moons. Much to your surprise, the sample contains a life-form that grows well in a rich broth. Your preliminary analysis shows that it is cellular and contains DNA, RNA, and protein. When you show your results to a colleague, she suggests that your sample was contaminated with an organism from Earth. What approaches might you try to distinguish between contamination and a novel cellular life-form based on DNA, RNA, and protein?

It is not so difficult to imagine what it means to feed on the organic molecules that living things produce. That is, after all, what we do. But what does it mean to feed on sunlight, as phototrophs do? Or, even stranger, to feed on rocks, as lithotrophs do? Where is the food, for example, in the mixture of chemicals (H2S, H2, CO, Mn+, Fe2+, Ni2+, CH4, and NH4 +) that spews from a hydrothermal vent?

How many possible different trees (branching patterns) can in theory be drawn to display the evolution of bacteria, archaea, and eukaryotes, assuming that they all arose from a common ancestor?

The genes for ribosomal RNA are highly conserved (relatively few sequence changes) in all organisms on Earth; thus, they have evolved very slowly over time. Were ribosomal RNA genes born perfect?

Genes participating in informational processes such as replication, transcription, and translation are transferred between species much less often than are genes involved in metabolism. The basis for this inequality is unclear at present, but one suggestion is that it relates to the underlying complexity of the two types of processes. Informational processes tend to involve large aggregates of different gene products, whereas metabolic reactions are usually catalyzed by enzymes composed of a single protein. Why would the complexity of the underlying processinformational or metabolichave any effect on the rate of horizontal gene transfer?

Animal cells have neither cell walls nor chloroplasts, whereas plant cells have both. Fungal cells are somewhere in between; they have cell walls but lack chloroplasts. Are fungal cells more likely to be animal cells that gained the ability to make cell walls, or plant cells that lost their chloroplasts? This question represented a difficult issue for early investigators who sought to assign evolutionary relationships based solely on cell characteristics and morphology. How do you suppose that this question was eventually decided?

When plant hemoglobin genes were first discovered in legumes, it was so surprising to find a gene typical of animal blood that it was hypothesized that the plant gene arose by horizontal transfer from an animal. Many more hemoglobin genes have now been sequenced, and a phylogenetic tree based on some of these sequences is shown in Figure Q12. A. Does this tree support or refute the hypothesis that the plant hemoglobins arose by horizontal gene transfer? B. Supposing that the plant hemoglobin genes were originally derived from a parasitic nematode, for example, what would you expect the phylogenetic tree to look like?

Rates of evolution appear to vary in different lineages. For example, the rate of evolution in the rat lineage is significantly higher than in the human lineage. These rate differences are apparent whether one looks at changes in nucleotide sequences that encode proteins and are subject to selective pressure or at changes in noncoding nucleotide sequences, which are not under obvious selection pressure. Can you offer one or more possible explanations for the slower rate of evolutionary change in the human lineage versus the rat lineage?