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Biochemistry | 9th Edition | ISBN: 9781305961135 | Authors: Shawn O. Farrell, Owen M. McDougal, Mary K. Campbell
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Double Assurance: Fidelity in Protein Synthesis

Chapter 12, Problem 34

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QUESTION: The fidelity of protein synthesis is assured twice during protein synthesis. How and when?

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QUESTION: The fidelity of protein synthesis is assured twice during protein synthesis. How and when?

ANSWER:

Step 1 of 3

The fidelity of protein synthesis is assured through two key mechanisms during the process: Aminoacyl-tRNA Synthetases  and Ribosome Proofreading 

Aminoacyl-tRNA Synthetases (During tRNA Charging):

Aminoacyl-tRNA synthetases play a crucial role in maintaining fidelity during protein synthesis.

These enzymes attach the correct amino acid to the corresponding tRNA molecule, a process known as tRNA charging.

Each aminoacyl-tRNA synthetase specifically recognizes and binds to its corresponding amino acid and tRNA molecule to ensure accurate pairing.

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Double Assurance: Fidelity in Protein Synthesis
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Discover the Intricate Checks and Balances in Protein Synthesis Fidelity: Join us in this video to unravel the two critical moments when the accuracy of protein synthesis is assured, shedding light on the 'how' and 'when' of this essential process.

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