As described in .84, the second step in tissueengineering | StudySoup

Textbook Solutions for Fundamentals of Heat and Mass Transfer

Chapter 7 Problem 7.144

Question

As described in 7.84, the second step in tissueengineering is to seed the top surface of the scaffoldwith human cells that subsequently grow into thepores of the scaffold. A seeding method that has beenproposed is to use a droplet generator similar to that of 7.84 to generate Dp?50 ?m diameter drops.The material in the droplet generator is a slurry con-sisting of a mixture of a host liquid and human livercells. The host liquid has properties similar to water,and the liver cells are spherical with a diameter ofDlc?20 ?m and density ?lc?2400 kg/m3. Dropletsare injected into atmospheric air with a relative humid-ity and temperature of ??0.50 and T??25?C,respectively. The particles are injected with an initialtemperature of Ti?25?C.(a) It is desirable for each drop to contain one livercell. Determine the volume fraction, f, of livercells in the slurry and the terminal velocity for adrop containing one liver cell.(b) The droplet containing one liver cell is injected atits terminal velocity. Determine the time of flightfor a distance between the ejector nozzle and thescaffold of L?4 mm. c) Determine the initial evaporation rate from thedroplet.(d) The tissue engineer is concerned that evaporationwill change the mass of the droplet and, in turn, willaffect its time of flight and the precision withwhich the seeds can be placed on the scaffold.Estimate the maximum change in mass due toevaporation during the time of flight. Compare thevariation of mass due to evaporation to the varia-tion associated with there being one to three livercells per droplet. Does evaporation or the liver cellpopulation per droplet influence the variability ofthe droplet mass most significantly?

Solution

Step 1 of 7)

The first step in solving 7 problem number 144 trying to solve the problem we have to refer to the textbook question: As described in 7.84, the second step in tissueengineering is to seed the top surface of the scaffoldwith human cells that subsequently grow into thepores of the scaffold. A seeding method that has beenproposed is to use a droplet generator similar to that of 7.84 to generate Dp?50 ?m diameter drops.The material in the droplet generator is a slurry con-sisting of a mixture of a host liquid and human livercells. The host liquid has properties similar to water,and the liver cells are spherical with a diameter ofDlc?20 ?m and density ?lc?2400 kg/m3. Dropletsare injected into atmospheric air with a relative humid-ity and temperature of ??0.50 and T??25?C,respectively. The particles are injected with an initialtemperature of Ti?25?C.(a) It is desirable for each drop to contain one livercell. Determine the volume fraction, f, of livercells in the slurry and the terminal velocity for adrop containing one liver cell.(b) The droplet containing one liver cell is injected atits terminal velocity. Determine the time of flightfor a distance between the ejector nozzle and thescaffold of L?4 mm. c) Determine the initial evaporation rate from thedroplet.(d) The tissue engineer is concerned that evaporationwill change the mass of the droplet and, in turn, willaffect its time of flight and the precision withwhich the seeds can be placed on the scaffold.Estimate the maximum change in mass due toevaporation during the time of flight. Compare thevariation of mass due to evaporation to the varia-tion associated with there being one to three livercells per droplet. Does evaporation or the liver cellpopulation per droplet influence the variability ofthe droplet mass most significantly?
From the textbook chapter External Flow you will find a few key concepts needed to solve this.

Step 2 of 7)

Visible to paid subscribers only

Step 3 of 7)

Visible to paid subscribers only

Subscribe to view the
full solution

Title Fundamentals of Heat and Mass Transfer 7 
Author Theodore L. Bergman; Adrienne S. Lavine; Frank P. Incropera; David P. DeWitt
ISBN 9780470501979

As described in .84, the second step in tissueengineering

Chapter 7 textbook questions

×

Login

Organize all study tools for free

Or continue with
×

Register

Sign up for access to all content on our site!

Or continue with

Or login if you already have an account

×

Reset password

If you have an active account we’ll send you an e-mail for password recovery

Or login if you have your password back