A researcher believes the median from population 1 is less than the median from population 2 in matched-pairs data. How would you define MD? How would you compute the differences?
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Textbook Solutions for Statistics: Informed Decisions Using Data
Question
Effect of Aspirin on Blood Clotting Blood clotting is due to a sequence of chemical reactions. The protein thrombin initiates blood clotting by working with another protein, prothrombin. It is common to measure an individuals blood clotting time as prothrombin time, the time between the start of the thrombin prothrombin reaction and the formation of the clot. Researchers wanted to study the effect of aspirin on prothrombin time. They randomly selected 12 subjects and measured the prothrombin time (in seconds) without taking aspirin and 3 hours after taking two aspirin tablets. They obtained the following data. Does the evidence suggest that aspirin affects the median time it takes for a clot to form? Use the a = 0.05 level of significance. Subject Before Aspirin After Aspirin Subject Before Aspirin After Aspirin 1 12.3 12.0 7 11.3 10.3 2 12.0 12.3 8 11.8 11.3 3 12.0 12.5 9 11.5 11.5 4 13.0 12.0 10 11.0 11.5 5 13.0 13.0 11 11.0 11.0 6 12.5 12.5 12 11.3 11.5 Source: Donald Yochem and Darrell Roach. Aspirin: Effect of Thrombus Formation Time and Prothrombin Time of Human Subjects. Angiology, 22:7076, 1971
Solution
The first step in solving 15.4 problem number 16 trying to solve the problem we have to refer to the textbook question: Effect of Aspirin on Blood Clotting Blood clotting is due to a sequence of chemical reactions. The protein thrombin initiates blood clotting by working with another protein, prothrombin. It is common to measure an individuals blood clotting time as prothrombin time, the time between the start of the thrombin prothrombin reaction and the formation of the clot. Researchers wanted to study the effect of aspirin on prothrombin time. They randomly selected 12 subjects and measured the prothrombin time (in seconds) without taking aspirin and 3 hours after taking two aspirin tablets. They obtained the following data. Does the evidence suggest that aspirin affects the median time it takes for a clot to form? Use the a = 0.05 level of significance. Subject Before Aspirin After Aspirin Subject Before Aspirin After Aspirin 1 12.3 12.0 7 11.3 10.3 2 12.0 12.3 8 11.8 11.3 3 12.0 12.5 9 11.5 11.5 4 13.0 12.0 10 11.0 11.5 5 13.0 13.0 11 11.0 11.0 6 12.5 12.5 12 11.3 11.5 Source: Donald Yochem and Darrell Roach. Aspirin: Effect of Thrombus Formation Time and Prothrombin Time of Human Subjects. Angiology, 22:7076, 1971
From the textbook chapter Inferences about the Difference between Two Medians: Dependent Samples you will find a few key concepts needed to solve this.
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