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The following drugs are synthesized using the methods in

Chapter 13, Problem 40SP

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QUESTION:

The following drugs are synthesized using the methods in this chapter and in previous chapters. Devise a synthesis for each, starting with any compounds containing no more than six carbon  atoms.

(a) Phenacetin, used with aspirin and caffeine in pain-relief medications.

(b) Methamphetamine, once considered a safe diet pill, but now known to be addictive and destructive to brain tissue.

(c) Dopamine, one of the neurotransmitters in the brain. Parkinson’s disease is thought to result from a dopamine deficiency.

\(\mathrm{CH}_{3} \mathrm{CH}_{2} \mathrm{O}\)

\(N H-C-C H_{3}\)

\(\mathrm{NHCH}_{3}\)

\(\mathrm{CH}_{2}-\mathrm{CH}-\mathrm{CH}_{3}\)

\(\mathrm{CH}_{2} \mathrm{CH}_{2} \mathrm{NH}_{2}\)

Equation transcription:

Text transcription:

{CH}{3}{CH}{2}{O}
N H-C-C H{3}

{NHCH}{3}

{CH}{2}-{CH}-{CH}{3}

{CH}{2}{CH}{2}{NH}{2}

Questions & Answers

QUESTION:

The following drugs are synthesized using the methods in this chapter and in previous chapters. Devise a synthesis for each, starting with any compounds containing no more than six carbon  atoms.

(a) Phenacetin, used with aspirin and caffeine in pain-relief medications.

(b) Methamphetamine, once considered a safe diet pill, but now known to be addictive and destructive to brain tissue.

(c) Dopamine, one of the neurotransmitters in the brain. Parkinson’s disease is thought to result from a dopamine deficiency.

\(\mathrm{CH}_{3} \mathrm{CH}_{2} \mathrm{O}\)

\(N H-C-C H_{3}\)

\(\mathrm{NHCH}_{3}\)

\(\mathrm{CH}_{2}-\mathrm{CH}-\mathrm{CH}_{3}\)

\(\mathrm{CH}_{2} \mathrm{CH}_{2} \mathrm{NH}_{2}\)

Equation transcription:

Text transcription:

{CH}{3}{CH}{2}{O}
N H-C-C H{3}

{NHCH}{3}

{CH}{2}-{CH}-{CH}{3}

{CH}{2}{CH}{2}{NH}{2}

ANSWER:

Solution 40SP

(a)        The synthesis of Phenacetin is given below -

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