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The following drugs are synthesized using the methods in
Chapter 13, Problem 40SP(choose chapter or problem)
The following drugs are synthesized using the methods in this chapter and in previous chapters. Devise a synthesis for each, starting with any compounds containing no more than six carbon atoms.
(a) Phenacetin, used with aspirin and caffeine in pain-relief medications.
(b) Methamphetamine, once considered a safe diet pill, but now known to be addictive and destructive to brain tissue.
(c) Dopamine, one of the neurotransmitters in the brain. Parkinson’s disease is thought to result from a dopamine deficiency.
\(\mathrm{CH}_{3} \mathrm{CH}_{2} \mathrm{O}\)
\(N H-C-C H_{3}\)
\(\mathrm{NHCH}_{3}\)
\(\mathrm{CH}_{2}-\mathrm{CH}-\mathrm{CH}_{3}\)
\(\mathrm{CH}_{2} \mathrm{CH}_{2} \mathrm{NH}_{2}\)
Equation transcription:
Text transcription:
{CH}{3}{CH}{2}{O}
N H-C-C H{3}
{NHCH}{3}
{CH}{2}-{CH}-{CH}{3}
{CH}{2}{CH}{2}{NH}{2}
Questions & Answers
QUESTION:
The following drugs are synthesized using the methods in this chapter and in previous chapters. Devise a synthesis for each, starting with any compounds containing no more than six carbon atoms.
(a) Phenacetin, used with aspirin and caffeine in pain-relief medications.
(b) Methamphetamine, once considered a safe diet pill, but now known to be addictive and destructive to brain tissue.
(c) Dopamine, one of the neurotransmitters in the brain. Parkinson’s disease is thought to result from a dopamine deficiency.
\(\mathrm{CH}_{3} \mathrm{CH}_{2} \mathrm{O}\)
\(N H-C-C H_{3}\)
\(\mathrm{NHCH}_{3}\)
\(\mathrm{CH}_{2}-\mathrm{CH}-\mathrm{CH}_{3}\)
\(\mathrm{CH}_{2} \mathrm{CH}_{2} \mathrm{NH}_{2}\)
Equation transcription:
Text transcription:
{CH}{3}{CH}{2}{O}
N H-C-C H{3}
{NHCH}{3}
{CH}{2}-{CH}-{CH}{3}
{CH}{2}{CH}{2}{NH}{2}
ANSWER:Solution 40SP
(a) The synthesis of Phenacetin is given below -